Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy
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چکیده
منابع مشابه
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy
TBN, a novel tetramethylpyrazine derivative armed with a powerful free radical-scavenging nitrone moiety, has been reported to reduce cerebral infarction in rats through multi-functional mechanisms of action. Here we study the therapeutic effects of TBN on non-human primate model of stroke. Thirty male Cynomolgus macaques were subjected to stroke with 4 hours ischemia and then reperfusion. TBN ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep37148